Dermatology

Dermatology

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Axial Disease in Psoriatic Arthritis study: defining the clinical and radiographic phenotype of psoriatic spondyloarthritis.

Jadon DR, Sengupta R, Nightingale A, Lindsay M, Korendowych E, Robinson G, et al. Axial Disease in Psoriatic Arthritis study: defining the clinical and radiographic phenotype of psoriatic spondyloarthritis. Annals of the rheumatic diseases. 2017;76(4):701-7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530328/

The recent ADIPSA (Axial Disease In PSoriatic Arthritis [PsA]) study found that 49/201 (23.9% ) of PsA patients fulfilled Modified New York criteria for ankylosing spondylitis (radiographic axial SpA). Although due to lack of MRI, fulfilment of the full ASAS criteria could not be assessed, 85/118 (72%) of Psoriatic SpA cases and 9/127 (7%) of peripheral PsA cases fulfilled ASAS clinical or radiographic imaging criteria.

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High prevalence of hidradenitis suppurativa symptoms in axial spondyloarthritis patients: A possible new extra-articular manifestation.

Rondags A, Arends S, Wink FR, Horváth B, Spoorenberg A. High prevalence of hidradenitis suppurativa symptoms in axial spondyloarthritis patients: A possible new extra-articular manifestation. Seminars in Arthritis and Rheumatism. 2019;48(4):611-7. https://www.sciencedirect.com/science/article/pii/S0049017218300155

Interestingly, hidradenitis suppurativa (HS) has recently also been implicated as a potential additional EAM of axial SpA. SpA and HS share several clinical and pathophysiological features, such as the association with IBD, and with elevated cytokine levels IL-17 and TNF-α. Recently, SpA was reported to be more prevalent (2.3–28.2%) in patients with HS than in the general population. The present study found that in a cohort of axial SpA patients, HS is more prevalent than in the general population (9.1% versus 0.053–4.1%). HS is associated with female gender, lower QoL, and especially higher axial SpA disease activity.

Symptoms starting slowly

Pain in the lower back

Improves with movement

Night time waking

Early onset (under 40)