The recent ADIPSA (Axial Disease In PSoriatic Arthritis [PsA]) study found that 49/201 (23.9% ) of PsA patients fulfilled Modified New York criteria for ankylosing spondylitis (radiographic axial SpA). Although due to lack of MRI, fulfilment of the full ASAS criteria could not be assessed, 85/118 (72%) of Psoriatic SpA cases and 9/127 (7%) of peripheral PsA cases fulfilled ASAS clinical or radiographic imaging criteria.
Interestingly, hidradenitis suppurativa (HS) has recently also been implicated as a potential additional EAM of axial SpA. SpA and HS share several clinical and pathophysiological features, such as the association with IBD, and with elevated cytokine levels IL-17 and TNF-α. Recently, SpA was reported to be more prevalent (2.3–28.2%) in patients with HS than in the general population. The present study found that in a cohort of axial SpA patients, HS is more prevalent than in the general population (9.1% versus 0.053–4.1%). HS is associated with female gender, lower QoL, and especially higher axial SpA disease activity.
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